Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for...

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Publicat a:Respir Res
Autors principals: Petersen, Bodil, Busch, Cornelius J., Schleifer, Grigorij, Schaack, Dominik, Lasitschka, Felix, Bloch, Kenneth D., Bloch, Donald B., Ichinose, Fumito
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547543/
https://ncbi.nlm.nih.gov/pubmed/31159807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1062-6
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