Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators

We demonstrate that combined treatment with metformin (Met) or its mitochondria-targeted analog, mito-metformin (Mito-Met), and various iron chelators synergistically inhibits proliferation of pancreatic and triple-negative breast cancer cells. Previously, we reported that Met (at millimolar levels)...

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Vydáno v:Oncotarget
Hlavní autoři: Cheng, Gang, Zielonka, Jacek, Hardy, Micael, Ouari, Olivier, Chitambar, Christopher R., Dwinell, Michael B., Kalyanaraman, Balaraman
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544408/
https://ncbi.nlm.nih.gov/pubmed/31191823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26943
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