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Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators
We demonstrate that combined treatment with metformin (Met) or its mitochondria-targeted analog, mito-metformin (Mito-Met), and various iron chelators synergistically inhibits proliferation of pancreatic and triple-negative breast cancer cells. Previously, we reported that Met (at millimolar levels)...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544408/ https://ncbi.nlm.nih.gov/pubmed/31191823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26943 |
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