Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington’s disease in the R6/2 mouse model

Huntington’s disease (HD) is an inherited progressive neurodegenerative disease characterized by motor, cognitive, and behavioural changes. One of the earliest changes to occur in HD is a reduction in cannabinoid 1 receptor (CB(1)) levels in the striatum, which is strongly correlated with HD pathoge...

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Pubblicato in:Neuropharmacology
Autori principali: Laprairie, Robert B, Bagher, Amina M, Rourke, Jillian L, Zrein, Adel, Cairns, Elizabeth A, Kelly, Melanie E M, Sinal, Christopher J, Kulkarni, Pushkar M, Thakur, Ganesh A, Denovan-Wright, Eileen M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544167/
https://ncbi.nlm.nih.gov/pubmed/30940536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.03.033
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