Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors

BACKGROUND AND PURPOSE: We sought to understand why (−)‐cannabidiol (CBD) and (−)‐cannabidiol‐dimethylheptyl (CBD‐DMH) exhibit distinct pharmacology, despite near identical structures. EXPERIMENTAL APPROACH: HEK293A cells expressing either human type 1 cannabinoid (CB(1)) receptors or CB(2) receptor...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Tham, Mylyne, Yilmaz, Orhan, Alaverdashvili, Mariam, Kelly, Melanie E M, Denovan‐Wright, Eileen M, Laprairie, Robert B
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Themed Section: Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487556/
https://ncbi.nlm.nih.gov/pubmed/29981240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14440
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