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Cannabidiol is a negative allosteric modulator of the cannabinoid CB(1) receptor

BACKGROUND AND PURPOSE: Cannabidiol has been reported to act as an antagonist at cannabinoid CB(1) receptors. We hypothesized that cannabidiol would inhibit cannabinoid agonist activity through negative allosteric modulation of CB(1) receptors. EXPERIMENTAL APPROACH: Internalization of CB(1) recepto...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Laprairie, R B, Bagher, A M, Kelly, M E M, Denovan‐Wright, E M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621983/
https://ncbi.nlm.nih.gov/pubmed/26218440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13250
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