Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the known allosteric modulators of CB1R. Indometha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Mol Neurosci
Prif Awduron: Laprairie, Robert B., Mohamed, Kawthar A., Zagzoog, Ayat, Kelly, Melanie E. M., Stevenson, Lesley A., Pertwee, Roger, Denovan-Wright, Eileen M., Thakur, Ganesh A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813218/
https://ncbi.nlm.nih.gov/pubmed/31680861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00257
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