Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

[Image: see text] Undesirable side effects associated with orthosteric agonists/antagonists of cannabinoid 1 receptor (CB1R), a tractable target for treating several pathologies affecting humans, have greatly limited their translational potential. Recent discovery of CB1R negative allosteric modulat...

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Publicado en:J Med Chem
Main Authors: Kulkarni, Pushkar M., Kulkarni, Abhijit R., Korde, Anisha, Tichkule, Ritesh B., Laprairie, Robert B., Denovan-Wright, Eileen M., Zhou, Han, Janero, David R., Zvonok, Nikolai, Makriyannis, Alexandros, Cascio, Maria G., Pertwee, Roger G., Thakur, Ganesh A.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716578/
https://ncbi.nlm.nih.gov/pubmed/26529344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01303
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