Mass Spectrometry-based Proteomics of Human Cannabinoid Receptor 2: Covalent Cysteine 6.47(257)-Ligand Interaction Affording Megagonist Receptor Activation

The lack of experimental characterization of the structures and ligand-binding motifs of therapeutic G-protein coupled receptors (GPCRs) hampers rational drug discovery. The human cannabinoid receptor 2 (hCB2R) is a class-A GPCR and promising therapeutic target for small-molecule cannabinergic agoni...

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Bibliografiset tiedot
Päätekijät: Szymanski, Dennis W., Papanastasiou, Malvina, Melchior, Katja, Zvonok, Nikolai, Mercier, Richard W., Janero, David R., Thakur, Ganesh, Cha, Sangwon, Wu, Billy, Karger, Barry, Makriyannis, Alexandros
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189276/
https://ncbi.nlm.nih.gov/pubmed/21861534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr2005583
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