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Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing
The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation. We studied the expression level of a questionable (Q) HLA-B*38:68Q allele, which carries a 9-nucleotide (nt) deletion at codon 230–232 in ex...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6542842/ https://ncbi.nlm.nih.gov/pubmed/31147565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44336-7 |
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