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Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
The bacterial CRISPR–Cas9 system has emerged as a multifunctional platform for sequence-specific regulation of gene expression. This Review describes the development of technologies based on nuclease-deactivated Cas9, termed dCas9, for RNA-guided genomic transcription regulation, both by repression...
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Foilsithe in: | Nat Rev Mol Cell Biol |
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Main Authors: | , , |
Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
2015
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922510/ https://ncbi.nlm.nih.gov/pubmed/26670017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2015.2 |
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