Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer

Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise in the oropharynx, where viral expression of the E6 and E7 oncoproteins promote cellular transformation, tumor growth, and maintenance. An important oncogenic signaling...

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Publicado no:Cancer Res
Main Authors: Brand, Toni M., Hartmann, Stefan, Bhola, Neil E., Li, Hua, Zeng, Yan, O’Keefe, Rachel A., Ranall, Max V., Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J., Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E., Ozbun, Michelle A., Bauman, Julie E., Grandis, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537867/
https://ncbi.nlm.nih.gov/pubmed/29440171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1672
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