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Targeting the IL-6/JAK/STAT3 signalling axis in cancer

The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...

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Détails bibliographiques
Publié dans:Nat Rev Clin Oncol
Auteurs principaux: Johnson, Daniel E., O’Keefe, Rachel A., Grandis, Jennifer R.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858971/
https://ncbi.nlm.nih.gov/pubmed/29405201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2018.8
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