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Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor
Drug-target binding kinetics are suggested to be important parameters for the prediction of in vivo drug-efficacy. For G protein-coupled receptors (GPCRs), the binding kinetics of ligands are typically determined using association binding experiments in competition with radiolabelled probes, followe...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6536503/ https://ncbi.nlm.nih.gov/pubmed/31133718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44025-5 |
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