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Estrogen Inhibition Reverses Pulmonary Arterial Hypertension and Associated Metabolic Defects

Increased estrogen is a strong epidemiologic risk factor for development of pulmonary arterial hypertension (PAH) in patients, associated with metabolic defects. Estrogens also drive penetrance in mice carrying mutations in BMPR2, the cause of most heritable PAH. The goal of the present study was to...

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Pubblicato in:Eur Respir J
Autori principali: Chen, Xinping, Austin, Eric D., Talati, Megha, Fessel, Joshua P, Farber-Eger, Eric H., Brittain, Evan L., Hemnes, Anna R, Loyd, James E., West, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532788/
https://ncbi.nlm.nih.gov/pubmed/28775043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02337-2016
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