Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension

Rationale: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation,...

詳細記述

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書誌詳細
主要な著者: Hemnes, Anna R., Brittain, Evan L., Trammell, Aaron W., Fessel, Joshua P., Austin, Eric D., Penner, Niki, Maynard, Karen B., Gleaves, Linda, Talati, Megha, Absi, Tarek, DiSalvo, Thomas, West, James
フォーマット: Artigo
言語:Inglês
出版事項: American Thoracic Society 2014
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977729/
https://ncbi.nlm.nih.gov/pubmed/24274756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1086OC
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