Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension

Rationale: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation,...

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Detalhes bibliográficos
Main Authors: Hemnes, Anna R., Brittain, Evan L., Trammell, Aaron W., Fessel, Joshua P., Austin, Eric D., Penner, Niki, Maynard, Karen B., Gleaves, Linda, Talati, Megha, Absi, Tarek, DiSalvo, Thomas, West, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977729/
https://ncbi.nlm.nih.gov/pubmed/24274756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1086OC
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