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Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension
Rationale: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation,...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Thoracic Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977729/ https://ncbi.nlm.nih.gov/pubmed/24274756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1086OC |
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