Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension

Rationale: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation,...

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Autori principali: Hemnes, Anna R., Brittain, Evan L., Trammell, Aaron W., Fessel, Joshua P., Austin, Eric D., Penner, Niki, Maynard, Karen B., Gleaves, Linda, Talati, Megha, Absi, Tarek, DiSalvo, Thomas, West, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977729/
https://ncbi.nlm.nih.gov/pubmed/24274756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201306-1086OC
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