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Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

BACKGROUND: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct critical periods during neurodevelopment in which reactivation of Ube3a gene expression can prevent the onset of behavioral defic...

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Bibliografski detalji
Izdano u:Mol Autism
Glavni autori: Sonzogni, Monica, Hakonen, Johanna, Bernabé Kleijn, Mireia, Silva-Santos, Sara, Judson, Matthew C., Philpot, Benjamin D., van Woerden, Geeske M., Elgersma, Ype
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532248/
https://ncbi.nlm.nih.gov/pubmed/31143434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-019-0277-1
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