Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

BACKGROUND: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct critical periods during neurodevelopment in which reactivation of Ube3a gene expression can prevent the onset of behavioral defic...

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Bibliographic Details
Published in:Mol Autism
Main Authors: Sonzogni, Monica, Hakonen, Johanna, Bernabé Kleijn, Mireia, Silva-Santos, Sara, Judson, Matthew C., Philpot, Benjamin D., van Woerden, Geeske M., Elgersma, Ype
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532248/
https://ncbi.nlm.nih.gov/pubmed/31143434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-019-0277-1
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