GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility

Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuron
Prif Awduron: Judson, Matthew C., Wallace, Michael L., Sidorov, Michael S., Burette, Alain C., Gu, Bin, van Woerden, Geeske M., King, Ian F., Han, Ji Eun, Zylka, Mark J., Elgersma, Ype, Weinberg, Richard J., Philpot, Benjamin D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824651/
https://ncbi.nlm.nih.gov/pubmed/27021170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.02.040
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