GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility

Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuron
Hlavní autoři: Judson, Matthew C., Wallace, Michael L., Sidorov, Michael S., Burette, Alain C., Gu, Bin, van Woerden, Geeske M., King, Ian F., Han, Ji Eun, Zylka, Mark J., Elgersma, Ype, Weinberg, Richard J., Philpot, Benjamin D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824651/
https://ncbi.nlm.nih.gov/pubmed/27021170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.02.040
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky