Adult Ube3a Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome

E3 ubiquitin ligase (UBE3A) levels in the brain need to be tightly regulated, as loss of functional UBE3A protein is responsible for the severe neurodevelopmental disorder Angelman syndrome (AS), whereas increased activity of UBE3A is associated with nonsyndromic autism. Given the role of mPFC in ne...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Rotaru, Diana C., van Woerden, Geeske M., Wallaard, Ilse, Elgersma, Ype
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2018
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596147/
https://ncbi.nlm.nih.gov/pubmed/30082419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0083-18.2018
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