Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs

Two mutations, G112D and M230I, were selected in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) by a novel nonnucleoside reverse transcriptase inhibitor (NNRTI). G112D is located near the HIV-1 polymerase active site; M230I is located near the hydrophobic region where...

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Publicado en:J Virol
Autores principales: Boyer, Paul L., Melody, Kevin, Smith, Steven J., Dunn, Linda L., Kline, Chris, Fischer, Douglas K., Dwivedi, Richa, Clark, Pat, Hughes, Stephen H., Ambrose, Zandrea
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532099/
https://ncbi.nlm.nih.gov/pubmed/30894467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00224-19
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