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Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity

Background: Bupivacaine (Bup) is the most commonly used local anesthetic. However, Bup induces cytotoxicity, especially in older patients. Recent reports have indicated that andrographolide (Andro) exhibits protective effects on human neurons. Nevertheless, whether Andro can inhibit Bup-induced cyto...

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Publicat a:Drug Des Devel Ther
Autors principals: Zhang, Huiyuan, Wang, Weiwei, Du, Qian
Format: Artigo
Idioma:Inglês
Publicat: Dove 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529178/
https://ncbi.nlm.nih.gov/pubmed/31190744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S201122
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