Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells. The transcription factor forkhead box p3 (Foxp3) play...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Dao, Tao, Mun, Sung Soo, Scott, Andrew C., Jarvis, Casey A., Korontsvit, Tatyana, Yang, Zhiyuan, Liu, Lianxing, Klatt, Martin G., Guerreiro, Manuel, Selvakumar, Annamalai, Brea, Elliott J., Oh, Claire, Liu, Cheng, Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527296/
https://ncbi.nlm.nih.gov/pubmed/31143508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1570778
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