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Structure of a TCR mimic antibody with target predicts pharmacogenetics
Antibody therapies currently target only extracellular antigens. A strategy to recognize intracellular antigens is to target peptides presented by immune HLA receptors. ESK1 is a human, T-cell receptor (TCR)-mimic antibody that binds with sub-nanomolar affinity to the RMF peptide from the intracellu...
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| 出版年: | J Mol Biol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4738012/ https://ncbi.nlm.nih.gov/pubmed/26688548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.12.002 |
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