Structure of a TCR mimic antibody with target predicts pharmacogenetics

Antibody therapies currently target only extracellular antigens. A strategy to recognize intracellular antigens is to target peptides presented by immune HLA receptors. ESK1 is a human, T-cell receptor (TCR)-mimic antibody that binds with sub-nanomolar affinity to the RMF peptide from the intracellu...

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Gepubliceerd in:J Mol Biol
Hoofdauteurs: Ataie, Niloufar, Xiang, Jingyi, Cheng, Neal, Brea, Elliott J., Lu, Wenjie, Scheinberg, David A., Liu, Cheng, Ng, Ho Leung
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738012/
https://ncbi.nlm.nih.gov/pubmed/26688548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.12.002
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