TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant lymphoproliferative disease (PTLD), all of which express the EBV protein latent membrane protein 2A (LMP2A), an antigen that is d...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Ahmed, Mahiuddin, Lopez-Albaitero, Andres, Pankov, Dmitry, Santich, Brian H., Liu, Hong, Yan, Su, Xiang, Jingyi, Wang, Pei, Hasan, Aisha N., Selvakumar, Annamalai, O’Reilly, Richard J., Liu, Cheng, Cheung, Nai-Kong V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916246/
https://ncbi.nlm.nih.gov/pubmed/29467338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97805
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