TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant lymphoproliferative disease (PTLD), all of which express the EBV protein latent membrane protein 2A (LMP2A), an antigen that is d...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ahmed, Mahiuddin, Lopez-Albaitero, Andres, Pankov, Dmitry, Santich, Brian H., Liu, Hong, Yan, Su, Xiang, Jingyi, Wang, Pei, Hasan, Aisha N., Selvakumar, Annamalai, O’Reilly, Richard J., Liu, Cheng, Cheung, Nai-Kong V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916246/
https://ncbi.nlm.nih.gov/pubmed/29467338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97805
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