TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant lymphoproliferative disease (PTLD), all of which express the EBV protein latent membrane protein 2A (LMP2A), an antigen that is d...

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Vydáno v:JCI Insight
Hlavní autoři: Ahmed, Mahiuddin, Lopez-Albaitero, Andres, Pankov, Dmitry, Santich, Brian H., Liu, Hong, Yan, Su, Xiang, Jingyi, Wang, Pei, Hasan, Aisha N., Selvakumar, Annamalai, O’Reilly, Richard J., Liu, Cheng, Cheung, Nai-Kong V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916246/
https://ncbi.nlm.nih.gov/pubmed/29467338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97805
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