Opportunities and challenges for TCR mimic antibodies in cancer therapy

INTRODUCTION: Monoclonal antibodies (mAbs) are potent cancer therapeutic agents, but exclusively recognize cell-surface targets whereas most cancer-associated proteins are found intracellularly. Hence, potential cancer therapy targets such as overexpressed self-proteins, activated oncogenes, mutated...

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Veröffentlicht in:Expert Opin Biol Ther
Hauptverfasser: Chang, Aaron Y., Gejman, Ron S., Brea, Elliott J., Oh, Claire Y., Mathias, Melissa D., Pankov, Dmitry, Casey, Emily, Dao, Tao, Scheinberg, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936943/
https://ncbi.nlm.nih.gov/pubmed/27094818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14712598.2016.1176138
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