A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL(+) leukemias

Acute and chronic leukemias, including CD34(+) CML cells, demonstrate increased expression of the Wilms tumor gene 1 product (WT1), making WT1 an attractive therapeutic target. However, WT1 is a currently undruggable, intracellular protein. ESKM is a human IgG1 T-cell receptor mimic monoclonal antib...

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Detalhes bibliográficos
Main Authors: Dubrovsky, Leonid, Pankov, Dmitry, Brea, Elliott Joseph, Dao, Tao, Scott, Andrew, Yan, Su, O’Reilly, Richard J, Liu, Cheng, Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046427/
https://ncbi.nlm.nih.gov/pubmed/24723681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-549022
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