Therapeutic Efficacy of an Fc-Enhanced TCR-Like Antibody to the Intracellular WT1 Oncoprotein

PURPOSE: RMFPNAPYL (RMF), a WT1-derived CD8 T cell epitope presented by HLA-A*02:01, is a validated target for T-cell-based immunotherapy. We previously reported ESK1, a high avidity (Kd < 0.2nM), fully-human monoclonal antibody (mAb) specific for the WT1 RMF peptide/HLA-A*02:01 complex, which se...

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Detalhes bibliográficos
Main Authors: Veomett, Nicholas, Dao, Tao, Liu, Hong, Xiang, Jingyi, Pankov, Dmitry, Dubrovsky, Leonid, Whitten, Joseph A., Park, Sun-Mi, Korontsvit, Tatyana, Zakhaleva, Victoria, Casey, Emily, Curcio, Michael, Kharas, Michael G., O’Reilly, Richard J., Liu, Cheng, Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119489/
https://ncbi.nlm.nih.gov/pubmed/24850840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2756
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