Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response

Cyclic GMP-AMP synthase (cGAS) senses viral DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the ER-localized adaptor protein Mediator of IRF3 Activator (MITA) to initiate innate antiviral response. Human cytomegalovirus (HCMV) proteins can antagonize ho...

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Udgivet i:PLoS Pathog
Main Authors: Fu, Yu-Zhi, Guo, Yi, Zou, Hong-Mei, Su, Shan, Wang, Su-Yun, Yang, Qing, Luo, Min-Hua, Wang, Yan-Yi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527189/
https://ncbi.nlm.nih.gov/pubmed/31107917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007691
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