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RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
BACKGROUND: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AMP (cGAMP...
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| Publicado en: | Cell Biosci |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5944131/ https://ncbi.nlm.nih.gov/pubmed/29760876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-018-0233-3 |
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