G3BP1 promotes DNA binding and activation of cGAS

Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain–binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS by promoting the formation of la...

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Publicado no:Nat Immunol
Main Authors: Liu, Zhao-Shan, Cai, Hong, Xue, Wen, Wang, Miao, Xia, Tian, Li, Wan-Jin, Xing, Jia-Qing, Zhao, Ming, Huang, Yi-Jiao, Chen, Shuai, Wu, Sheng-Ming, Wang, Xinzheng, Liu, Xin, Pang, Xue, Zhang, Zi-Yu, Li, Tingting, Dai, Jiang, Dong, Fangting, Xia, Qing, Li, Ai-Ling, Zhou, Tao, Liu, Zheng-gang, Zhang, Xue-Min, Li, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276115/
https://ncbi.nlm.nih.gov/pubmed/30510222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0262-4
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