Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

The presence of DNA in the cytoplasm is normally a sign of microbial infections and is quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection immune responses. However, chronic activation of cGAS by self-DNA leads to severe autoimmune diseases for which no effective treatment is...

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Published in:Cell
Main Authors: Dai, Jiang, Huang, Yi-Jiao, He, Xinhua, Zhao, Ming, Wang, Xinzheng, Liu, Zhao-Shan, Xue, Wen, Cai, Hong, Zhan, Xiao-Yan, Huang, Shao-Yi, He, Kun, Wang, Hongxia, Wang, Na, Sang, Zhihong, Li, Tingting, Han, Qiu-Ying, Mao, Jie, Diao, Xinwei, Song, Nan, Chen, Yuan, Li, Wei-Hua, Man, Jiang-Hong, Li, Ai-Ling, Zhou, Tao, Liu, Zheng-Gang, Zhang, Xue-Min, Li, Tao
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274936/
https://ncbi.nlm.nih.gov/pubmed/30799039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.016
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