RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Li, Chenhui, Zhang, Lele, Qian, Dong, Cheng, Mingxing, Hu, Haiyang, Hong, Ze, Cui, Ye, Yu, Huansha, Wang, Quanyi, Zhu, Juanjuan, Meng, Wei, Xu, Jin-fu, Sun, Yi, Zhang, Peng, Wang, Chen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959372/
https://ncbi.nlm.nih.gov/pubmed/33720974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009401
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