The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2′3′-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modulated dyna...

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Publicat a:PLoS Pathog
Autors principals: Wang, Qiang, Huang, Liyuan, Hong, Ze, Lv, Zhongshi, Mao, Zhaomin, Tang, Yijun, Kong, Xiufang, Li, Senlin, Cui, Ye, Liu, Heng, Zhang, Lele, Zhang, Xiaojie, Jiang, Lindi, Wang, Chen, Zhou, Qin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358892/
https://ncbi.nlm.nih.gov/pubmed/28273161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006264
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