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The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.
The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2'3'-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modu...
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Main Authors: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science (PLoS)
2017-03-01
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Colecção: | PLoS Pathogens |
Acesso em linha: | http://europepmc.org/articles/PMC5358892?pdf=render |
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