The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.

The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2'3'-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modu...

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Autores principales: Qiang Wang, Liyuan Huang, Ze Hong, Zhongshi Lv, Zhaomin Mao, Yijun Tang, Xiufang Kong, Senlin Li, Ye Cui, Heng Liu, Lele Zhang, Xiaojie Zhang, Lindi Jiang, Chen Wang, Qin Zhou
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2017-03-01
Colección:PLoS Pathogens
Acceso en línea:http://europepmc.org/articles/PMC5358892?pdf=render
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