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RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
BACKGROUND: As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement of cGAS with DNA leads to the synthesis of a second messenger, cyclic GMP-AMP (cGAMP...
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| izdano v: | Cell Biosci |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5944131/ https://ncbi.nlm.nih.gov/pubmed/29760876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-018-0233-3 |
| Oznake: |
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