TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA domain (TEAD) proteins. Nonet...

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Publicado no:Am J Pathol
Main Authors: Zhang, Jie, Liu, Pin, Tao, Junyan, Wang, Pan, Zhang, Yi, Song, Xinhua, Che, Li, Sumazin, Pavel, Ribback, Silvia, Kiss, Andras, Schaff, Zsuzsa, Cigliano, Antonio, Dombrowski, Frank, Cossu, Carla, Pascale, Rosa M., Calvisi, Diego F., Monga, Satdarshan P., Chen, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526503/
https://ncbi.nlm.nih.gov/pubmed/30794805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.01.016
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