Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcinogenesis. β-catenin mutations can be in the form of point mutation or large N-t...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Qiao, Yu, Xu, Meng, Tao, Junyan, Che, Li, Cigliano, Antonio, Monga, Satdarshan P, Calvisi, Diego F, Chen, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233269/
https://ncbi.nlm.nih.gov/pubmed/30419856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4870-z
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