Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice

Inactivating mutations of axis inhibition protein 1 (AXIN1), a negative regulator of the Wnt/β-Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting approximately 10% of cases. In the present manuscript, we sought to define the genetic crosstalk betw...

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Publicat a:Hepatology
Autors principals: Qiao, Yu, Wang, Jingxiao, Karagoz, Eylul, Liang, Binyong, Song, Xinhua, Shang, Runze, Evert, Katja, Xu, Meng, Che, Li, Evert, Matthias, Calvisi, Diego F., Tao, Junyan, Wang, Bruce, Monga, Satdarshan P., Chen, Xin
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206928/
https://ncbi.nlm.nih.gov/pubmed/30737831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30556
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