TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis

BACKGROUND & AIMS: Gain of function (GOF) mutation of CTNNB1 gene is one of the most frequent genetic events in hepatocellular carcinoma (HCC). T-box transcription factor 3 (TBX3) is a liver-specific target of the Wnt/β-Catenin pathway and thought to be an oncogene mediating activated β-Catenin...

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Vydáno v:J Hepatol
Hlavní autoři: Liang, Binyong, Zhou, Yi, Qian, Manning, Xu, Meng, Wang, Jingxiao, Zhang, Yi, Song, Xinhua, Wang, Haichuan, Lin, Shumei, Ren, Chuanli, Monga, Satdarshan P., Wang, Bruce, Evert, Matthias, Chen, Yifa, Chen, Xiaoping, Huang, Zhiyong, Calvisi, Diego F., Chen, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217095/
https://ncbi.nlm.nih.gov/pubmed/33577921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2021.01.044
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