COMPLETE RESPONSE OF CTNNB1-MUTATED TUMORS TO β-CATENIN SUPPRESSION BY LOCKED NUCLEIC ANTISENSE IN MOUSE HEPATOCARCINOGENESIS MODEL

BACKGROUND AND AIMS: Hepatocellular cancer (HCC) remains a disease of poor prognosis highlighting the relevance of elucidating key molecular aberrations that may be targeted for novel therapies. Wnt signaling activation chiefly due to mutations in CTNNB1 have been identified in a major subset of HCC...

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Veröffentlicht in:J Hepatol
Hauptverfasser: Delgado, Evan, Okabe, Hirohisa, Preziosi, Morgan, Russell, Jacquelyn Olivia, Alvarado, Tamara Feliciano, Oertel, Michael, Nejak-Bowen, Kari Nichole, Zhang, Yixian, Monga, Satdarshan P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300253/
https://ncbi.nlm.nih.gov/pubmed/25457204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.021
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