Overexpression of SMAD7 activates the YAP/NOTCH cascade and promotes liver carcinogenesis in mice and humans

BACKGROUND & AIMS: Mothers against decapentaplegic homolog 7 (SMAD7) is an antagonist of the transforming growth factor β (TGF-β) signaling. In the present investigation, we sought to determine the relevance of SMAD7 in liver carcinogenesis using in vitro and in vivo approaches. APPROACH & R...

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Publicado no:Hepatology
Main Authors: Wang, Haichuan, Song, Xinhua, Liao, Haotian, Wang, Pan, Zhang, Yi, Che, Li, Zhang, Jie, Zhou, Yi, Cigliano, Antonio, Ament, Cindy, Superville, Daphne, Ribback, Silvia, Reeves, Melissa, Pes, Giovanni M., Liang, Binyong, Wu, Hong, Evert, Matthias, Calvisi, Diego F., Zeng, Yong, Chen, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222417/
https://ncbi.nlm.nih.gov/pubmed/33368437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31692
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