STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES

Gradients of VEGF induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip cell features in adjacent stalk cells via Dll4/Notch mediated lateral inhibition. We report here that Smad1/Smad5 mediated BMP signaling synergizes with Notch sig...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Moya, Iván M., Umans, Lieve, Maas, Elke, Pereira, Paulo N. G., Beets, Karen, Francis, Annick, Sents, Ward, Robertson, Elizabeth J., Mummery, Christine L., Huylebroeck, Danny, Zwijsen, An
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544746/
https://ncbi.nlm.nih.gov/pubmed/22364862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.01.007
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