STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES

Gradients of VEGF induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip cell features in adjacent stalk cells via Dll4/Notch mediated lateral inhibition. We report here that Smad1/Smad5 mediated BMP signaling synergizes with Notch sig...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Moya, Iván M., Umans, Lieve, Maas, Elke, Pereira, Paulo N. G., Beets, Karen, Francis, Annick, Sents, Ward, Robertson, Elizabeth J., Mummery, Christine L., Huylebroeck, Danny, Zwijsen, An
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544746/
https://ncbi.nlm.nih.gov/pubmed/22364862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.01.007
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