Inactivation of Smad5 in Endothelial Cells and Smooth Muscle Cells Demonstrates that Smad5 Is Required for Cardiac Homeostasis

Smads are intracellular signaling proteins that transduce signals elicited by members of the transforming growth factor (TGF)-β superfamily. Smad5 and Smad1 are highly homologous, and they mediate primarily bone morphogenetic protein (Bmp) signals. We used the Cre-loxP system and Sm22-Cre and Tie-1-...

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Hoofdauteurs: Umans, Lieve, Cox, Luk, Tjwa, Marc, Bito, Virginie, Vermeire, Liesbeth, Laperre, Kjell, Sipido, Karin, Moons, Lieve, Huylebroeck, Danny, Zwijsen, An
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854943/
https://ncbi.nlm.nih.gov/pubmed/17456754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060839
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