Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice

Anemia suppresses liver hepcidin expression to supply adequate iron for erythropoiesis. Erythroferrone mediates hepcidin suppression by anemia, but its mechanism of action remains uncertain. The bone morphogenetic protein (BMP)–SMAD signaling pathway has a central role in hepcidin transcriptional re...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Wang, Chia-Yu, Core, Amanda B., Canali, Susanna, Zumbrennen-Bullough, Kimberly B., Ozer, Sinan, Umans, Lieve, Zwijsen, An, Babitt, Jodie L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2017
Teme:
Red Cells, Iron, and Erythropoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501149/
https://ncbi.nlm.nih.gov/pubmed/28438754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-759423
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