Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts. Erythroferrone (ERFE) has been identified as the erythroid regulator that inhibits hepcidin in stress erythropoiesis. A pow...

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Publicado en:Blood
Autores principales: Nai, Antonella, Rubio, Aude, Campanella, Alessandro, Gourbeyre, Ophélie, Artuso, Irene, Bordini, Jessica, Gineste, Aurélie, Latour, Chloé, Besson-Fournier, Céline, Lin, Herbert Y., Coppin, Hélène, Roth, Marie-Paule, Camaschella, Clara, Silvestri, Laura, Meynard, Delphine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865590/
https://ncbi.nlm.nih.gov/pubmed/26755707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-681494
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