Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts. Erythroferrone (ERFE) has been identified as the erythroid regulator that inhibits hepcidin in stress erythropoiesis. A pow...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Nai, Antonella, Rubio, Aude, Campanella, Alessandro, Gourbeyre, Ophélie, Artuso, Irene, Bordini, Jessica, Gineste, Aurélie, Latour, Chloé, Besson-Fournier, Céline, Lin, Herbert Y., Coppin, Hélène, Roth, Marie-Paule, Camaschella, Clara, Silvestri, Laura, Meynard, Delphine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865590/
https://ncbi.nlm.nih.gov/pubmed/26755707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-681494
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